Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro.

@article{Zhang2011HypoxiaIA,
  title={Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro.},
  author={Jing Zhang and Fengbo Zhao and Yin Zhao and Jing Wang and Lei Pei and Ning Sun and Jing Shi},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 23},
  pages={20194-207}
}
TRPM7, a divalent cation channel, plays an important role in neurons damaged from cerebral ischemia due to permitting intracellular calcium overload. This study aimed to explore whether magnesium was transported via a TRPM7 channel into the intracellular space of rat hippocampal neurons after 1 h of oxygen-glucose deprivation (OGD) and acute chemical ischemia (CI) by using methods of the Mg(2+) fluorescent probe Mag-Fura-2 to detect intracellular magnesium concentration ([Mg(2+)](i)) and flame… CONTINUE READING

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