Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes.

@article{Kalra1996HypoxiaIP,
  title={Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes.},
  author={Vijay K. Kalra and Yamin Shen and Chand Sultana and V Rattan},
  journal={The American journal of physiology},
  year={1996},
  volume={271 5 Pt 2},
  pages={H2025-34}
}
Polymorphonuclear neutrophils (PMN) adhere to the vascular endothelium under hypoxic conditions, causing microvascular injury. The molecular mechanism of hypoxia-induced adhesion of PMN to and diapedesis through the vascular endothelium is poorly understood. We examined the effects of hypoxia on the transendothelial migration of monocytes. Exposure of human umbilical vein endothelial cells (HUVEC) cultured in Transwell chambers under low oxygen tension (3% O2 compared with 21% O2) resulted in… CONTINUE READING