Hypoxia induced upregulation of miR-301a/b contributes to increased cell autophagy and viability of prostate cancer cells by targeting NDRG2.

@article{Guo2016HypoxiaIU,
  title={Hypoxia induced upregulation of miR-301a/b contributes to increased cell autophagy and viability of prostate cancer cells by targeting NDRG2.},
  author={Yan -Shi Guo and Jianxin Liu and Yinglu Guan},
  journal={European review for medical and pharmacological sciences},
  year={2016},
  volume={20 1},
  pages={
          101-8
        }
}
OBJECTIVE Previous studies reported that NDRG2 might be a tumor suppressor of prostate cancer. In this study, we investigated the hypoxia-induced expression change of miR-301a/b in prostate cancer cells and explored its regulation on NDRG2 in autophagy and viability of prostate cancer cells. MATERIALS AND METHODS MiR-301a/b expression in hypoxia and normoxia cultured prostate cancer cells was measured. Its regulation on autophagy was measured by quantifying expression change of LC3B and p62… CONTINUE READING
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