Hypoxia-induced tetraploidisation of a diploid human melanoma cell line in vitro.

@article{Rofstad1996HypoxiainducedTO,
  title={Hypoxia-induced tetraploidisation of a diploid human melanoma cell line in vitro.},
  author={Einar K. Rofstad and N M Johnsen and Heidi Lyng},
  journal={The British journal of cancer. Supplement},
  year={1996},
  volume={27},
  pages={S136-9}
}
Many human tumours are hyperdiploid, particularly in advanced stages of growth. The purpose of the present work was to investigate whether exposure to hypoxia followed by reoxygenation might induce hyperploidisation of diploid human tumour cells in vitro. The investigation was performed by using the diploid melanoma cell line BEX-c (median chromosome number, 46; DNA index, 1.10 +/- 0.04) as test line and the hyperdiploid melanoma cell line SAX-c (median chromosome number, 61; DNA index, 1.42… CONTINUE READING

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