Hypoxia-induced synthesis of hemoglobin in the crustacean Daphnia magna is hypoxia-inducible factor-dependent.

@article{Gorr2004HypoxiainducedSO,
  title={Hypoxia-induced synthesis of hemoglobin in the crustacean Daphnia magna is hypoxia-inducible factor-dependent.},
  author={Thomas A Gorr and Joshua D Cahn and Hideo Yamagata and H. Franklin Bunn},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 34},
  pages={36038-47}
}
Of the four known globin genes that exist in the fresh-water crustacean Daphnia magna, several are individually induced by hypoxia, lending pale normoxic animals a visible red color when challenged by oxygen deprivation. The promoter regions of the Daphnia globin genes each contain numerous hypoxia response elements (HREs) as potential binding sites for hypoxia-inducible factors (HIFs). Daphnia HIF, bound to human HRE sequences, was detected in extracts from hypoxic (red), but not normoxic… CONTINUE READING
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