Hypoxia-induced redox alterations and their correlation with 99mTc-MIBI and 99mTc-HL-91 uptake in colon cancer cells.

@article{Abrantes2010HypoxiainducedRA,
  title={Hypoxia-induced redox alterations and their correlation with 99mTc-MIBI and 99mTc-HL-91 uptake in colon cancer cells.},
  author={Ana M Abrantes and Maria Elisa Silva Serra and Ana C Gonçalves and Joana Rio and B{\'a}rbara Oliveiros and Mafalda Laranjo and Ant{\'o}nio Manuel Rocha-Gonsalves and Ana Bela Sarmento-Ribeiro and M. F. Botelho},
  journal={Nuclear medicine and biology},
  year={2010},
  volume={37 2},
  pages={125-32}
}
Colorectal cancer is one of the most common malignancies in the Western world and is an example of a solid tumour in which hypoxia is a common feature and develops because of the inability of the vascular system to supply adequate amounts of oxygen to growing tumours. Hypoxia effects on tumour cell biology can be detected and characterized using different methods. The use of imaging with gamma-emitting radionuclides to detect hypoxic tissue was first suggested by Chapman in 1979 [N Engl J Med… CONTINUE READING