Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene.

@article{Norris1995HypoxiainducedPB,
  title={Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene.},
  author={Michael L. Norris and David E. Millhorn},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 40},
  pages={23774-9}
}
We reported recently that the gene that encodes tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is regulated by hypoxia in the dopaminergic cells of the mammalian carotid body (Czyzyk-Krzeska, M. F., Bayliss, D. A., Lawson, E. E. & Millhorn, D. E. (1992) J. Neurochem. 58, 1538-1546) and in pheochromocytoma (PC12) cells (Czyzyk-Krzeska, M. F., Furnari, B. A., Lawson, E. E. & Millhorn, D. E. (1994) J. Biol. Chem. 269, 760-764). Regulation of this gene… CONTINUE READING

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