Hypoxia induced multidrug resistance of laryngeal cancer cells via hypoxia-inducible factor-1α.

  title={Hypoxia induced multidrug resistance of laryngeal cancer cells via hypoxia-inducible factor-1α.},
  author={Da-wei Li and Pin Dong and Fei Wang and Xin-wei Chen and Cheng-zhi Xu and Liang Zhou},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  volume={14 8},
OBJECTIVES To investigate whether hypoxia has an effect on regulation of multidrug resistance (MDR) to chemotherapeutic drugs in laryngeal carcinoma cells and explore the role of hypoxia-inducible factor-1α (HIF- 1α). METHODS Laryngeal cancer cells were cultured under normoxic and hypoxic conditions. The sensitivity of the cells to multiple drugs and levels of apoptosis induced by paclitaxel were determined by MTT assay and annexin-V/propidium iodide staining analysis, respectively. HIF-1… CONTINUE READING
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