Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism.

@article{YamajiKegan2010HypoxiainducedMF,
  title={Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism.},
  author={Kazuyo Yamaji-Kegan and Qingning Su and Daniel J. Angelini and Allen C. Myers and Chris Cheadle and Roger A. Johns},
  journal={Journal of immunology},
  year={2010},
  volume={185 9},
  pages={
          5539-48
        }
}
Hypoxia-induced mitogenic factor (HIMF), also known as found in inflammatory zone 1 and resistin-like molecule α, belongs to a novel class of cysteine-rich secreted proteins. It exhibits mitogenic and chemotactic properties during pulmonary hypertension-associated vascular remodeling, as well as fibrogenic properties during pulmonary fibrosis. HIMF expression in the lung was reported to be regulated by Th2 cytokines (IL-4 and IL-13) via the transcription factor STAT6 pathway in a bleomycin… CONTINUE READING

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