Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release.

@article{Decking1997HypoxiainducedIO,
  title={Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release.},
  author={Ulrich K. M. Decking and Gust. Schlieper and Keith Kroll and Jochen Schrader},
  journal={Circulation research},
  year={1997},
  volume={81 2},
  pages={
          154-64
        }
}
To elucidate the physiological role of the AMP-adenosine metabolic cycle and to investigate the relation between AMP and adenosine formation, the O2 supply of isolated guinea pig hearts was varied (95% to 10% O2). The net adenosine formation rate (AMP-->adenosine) and coronary venous effluent adenosine release rate were measured; free cytosolic AMP was determined by 31P-nuclear magnetic resonance. Switching from 95% to 40% O2 increased free AMP and adenosine formation 4-fold, whereas free… CONTINUE READING

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