Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.

@article{Park2003HypoxiainducedGE,
  title={Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.},
  author={Sang-ki Park and Agnes M Dadak and Volker H Haase and Lucrezia Fontana and Amato J. Giaccia and Randall S Johnson},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 14},
  pages={4959-71}
}
The hypoxia-inducible factors 1alpha (HIF-1alpha) and 2alpha (HIF-2alpha) have extensive structural homology and have been identified as key transcription factors responsible for gene expression in response to hypoxia. They play critical roles not only in normal development, but also in tumor progression. Here we report on the differential regulation of protein expression and transcriptional activity of HIF-1alpha and -2alpha by hypoxia in immortalized mouse embryo fibroblasts (MEFs). We show… CONTINUE READING