Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH.

@article{Srensen2007HypoxiaIE,
  title={Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH.},
  author={Brita Singers S\orensen and Jan Alsner and Jens Overgaard and Michael Robert Horsman},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2007},
  volume={83 3},
  pages={362-6}
}
BACKGROUND Genes such as carbonic anhydrase IX (Ca9), glucose transporter 1 (Glut1), lactate dehydrogenase A (LDH-A), osteopontin (OPN) and lysyl oxidase (LOX) have been suggested as hypoxic markers, but inconsistent results suggest that factors other than oxygen influence their expression. The current study is a detailed investigation using a range of pH values from 6.3 to 7.5 in two human cell lines to establish the pH dependency of hypoxia induced gene expression. METHODS Human tumour cell… CONTINUE READING