Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response.

@article{Beucken2009HypoxiainducedEO,
  title={Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response.},
  author={Twan van den Beucken and Marianne Koritzinsky and Hanneke Niessen and Ludwig Dubois and Kim G. M. Savelkouls and Hilda Mujcic and Barry Jutten and Juraj Kop{\'a}cek and Sylvia Pastorekova and Albert J van der Kogel and Philippe Lambin and Willem Voncken and Kasper M A Rouschop and Bradly G. Wouters},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 36},
  pages={24204-12}
}
Adaptation to tumor hypoxia is mediated in large part by changes in protein expression. These are driven by multiple pathways, including activation of the hypoxia inducible factor-1 (HIF-1) transcription factor and the PKR-like endoplasmic reticulum kinase PERK, a component of the unfolded protein response. Through gene expression profiling we discovered that induction of the HIF-1 target gene CA9 was defective in mouse embryo fibroblasts derived from mice harboring an eIF2alpha S51A knock-in… CONTINUE READING

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