Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.

  title={Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.},
  author={Ranjit S Bindra and Shannon L Gibson and Alice F. Meng and Ulrica K Westermark and Maria Jasin and Andrew J. Pierce and Robert G. Bristow and Marie K. Classon and Peter M. Glazer},
  journal={Cancer research},
  volume={65 24},
Decreased BRCA1 expression in the absence of genetic mutation is observed frequently in sporadic cancers of the breast and other sites, although little is known regarding the mechanisms by which the expression of this gene can be repressed. Here, we show that activating and repressive E2Fs simultaneously bind the BRCA1 promoter at two adjacent E2F sites in vivo, and that hypoxia induces a dynamic redistribution of promoter occupancy by these factors resulting in the transcriptional repression… CONTINUE READING
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