Hypoxia-induced bFGF gene expression is mediated through the JNK signal transduction pathway

@article{Lee1999HypoxiainducedBG,
  title={Hypoxia-induced bFGF gene expression is mediated through the JNK signal transduction pathway},
  author={Yong Joo Lee and Peter M. Corry},
  journal={Molecular and Cellular Biochemistry},
  year={1999},
  volume={202},
  pages={1-8}
}
Although the synthesis of angiogenic factors in hypoxic regions of solid tumors is recognized as one of the critical steps in tumor growth and metastasis, the signal transduction pathway involved in hypoxic induction of basic fibroblast growth factor (bFGF) gene expression is still obscure. In the study described here, we investigated the intracellular responses to hypoxia and the mechanisms triggering the initiation of angiogenic activity in drug-resistant human breast carcinoma MCF-7/ADR… CONTINUE READING

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Trends in biochemical sciences • 1992
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