Hypoxia-induced angiogenesis is delayed in aging mouse brain.

  title={Hypoxia-induced angiogenesis is delayed in aging mouse brain.},
  author={Girriso F. Benderro and Joseph C. LaManna},
  journal={Brain research},
Chronic moderate hypoxia results in systemic and central nervous system adaptations that allow acclimatization. Long-term responses to hypoxia involve systemic physiological changes, metabolic regulation, and vascular remodeling. To investigate whether aging affects systemic and cerebral angiogenic adaptational changes in response to prolonged hypoxia, the present study assessed the responses of 4month old ("young") C57BL/6 mice and 24month old ("aged") C57BL/6 mice to chronic hypobaric hypoxia… CONTINUE READING


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