Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human melanoma.

@article{Rofstad1998HypoxiainducedAA,
  title={Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human melanoma.},
  author={Einar K. Rofstad and T. L. Danielsen},
  journal={British Journal of Cancer},
  year={1998},
  volume={77},
  pages={897 - 902}
}
Tumour cells exposed to hypoxia in vitro can show increased expression of several selected genes, including the gene encoding the vascular endothelial growth factor (VEGF), suggesting that hypoxia followed by reoxygenation might promote the malignant progression of tumours. An in vitro/in vivo study was conducted to investigate whether hypoxia can increase the angiogenic potential of tumour cells through increased VEGF secretion. Four human melanoma cell lines (A-07, D-12, R-18, U-25) were… CONTINUE READING