Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy.

@article{Kim2012HypoxiainducedSI,
  title={Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy.},
  author={Tae Rim Kim and Eun Wie Cho and Sang Gi Paik and In-Gyu Kim},
  journal={FEBS letters},
  year={2012},
  volume={586 4},
  pages={303-9}
}
Chemo- or radiation-resistance in tumors caused by hypoxia often undermines efficacy of cancer therapy. Thus, therapies that overcome cellular resistance during hypoxia are necessary. SM22α is an actin-binding protein found in smooth muscle, fibroblasts, and some epithelium. We demonstrate that SM22α is induced in A549 non-small cell lung carcinoma cells by hypoxia and its overexpression increased chemo- and radiation-resistance. Hypoxia-mediated induction of SM22α expression is hypoxia… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 27 references

SM22alpha-induced activation of p16INK4a/retinoblastoma pathway promotes cellular senescence caused by a subclinical dose of gamma-radiation and doxorubicin in HepG2 cells

T. R. Kim, H. M. Lee, +5 authors I. G. Kim
Biochem. Biophys. Res • 2010
View 6 Excerpts
Highly Influenced

Hypoxia and hypoxia-inducible factors: master regulators of metastasis.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2010
View 1 Excerpt

The PI3-K/AKT-pathway and radiation resistance mechanisms in non-small cell lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer • 2009
View 1 Excerpt

Transgelin: an actin-binding protein and tumour suppressor.

The international journal of biochemistry & cell biology • 2009
View 2 Excerpts

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