Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

@article{Xing2011HypoxiainducedJP,
  title={Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells},
  author={F. Xing and H. Okuda and M. Watabe and A. Kobayashi and S. K. Pai and W. Liu and P. R. Pandey and K. Fukuda and S. Hirota and T. Sugai and G. Wakabayshi and K. Koeda and M. Kashiwaba and K. Suzuki and T. Chiba and M. Endo and Y. Mo and K. Watabe},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={4075 - 4086}
}
Notch signaling is often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In this study, we aimed to define the mechanism of Notch-ligand activation by hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor progression. We have analyzed the expression profiles of various Notch ligands in 779 breast cancer… Expand
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References

SHOWING 1-10 OF 60 REFERENCES
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
Ligand-dependent Notch Signaling Is Involved in Tumor Initiation and Tumor Maintenance in Pancreatic Cancer
Notch1 is an effector of Akt and hypoxia in melanoma development.
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer.
Activation of Notch Signaling in a Xenograft Model of Brain Metastasis
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
Distinct Biological Roles for the Notch Ligands Jagged-1 and Jagged-2*
Hypoxia Enhances Tumor Stemness by Increasing the Invasive and Tumorigenic Side Population Fraction
Aberrant Activation of Notch Signaling in Human Breast Cancer
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