Hypoxia-independent downregulation of hypoxia-inducible factor 1 targets by androgen deprivation therapy in prostate cancer.

@article{Ragnum2013HypoxiaindependentDO,
  title={Hypoxia-independent downregulation of hypoxia-inducible factor 1 targets by androgen deprivation therapy in prostate cancer.},
  author={Harald Bull Ragnum and Kathrine R\oe and Ruth Holm and Ljiljana Vlatkovic and Jahn Marthin Nesland and Eva-Katrine Aarnes and Anne Hansen Ree and Kjersti Flatmark and Therese Seierstad and Wolfgang Lilleby and Heidi Lyng},
  journal={International journal of radiation oncology, biology, physics},
  year={2013},
  volume={87 4},
  pages={753-60}
}
PURPOSE We explored changes in hypoxia-inducible factor 1 (HIF1) signaling during androgen deprivation therapy (ADT) of androgen-sensitive prostate cancer xenografts under conditions in which no significant change in immunostaining of the hypoxia marker pimonidazole had occurred. METHODS AND MATERIALS Gene expression profiles of volume-matched androgen-exposed and androgen-deprived CWR22 xenografts, with similar pimonidazole-positive fractions, were compared. Direct targets of androgen… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS