Hypoxia increases the yield of photoreceptors differentiating from mouse embryonic stem cells and improves the modeling of retinogenesis in vitro.

@article{GaritaHernndez2013HypoxiaIT,
  title={Hypoxia increases the yield of photoreceptors differentiating from mouse embryonic stem cells and improves the modeling of retinogenesis in vitro.},
  author={Marcela Garita-Hern{\'a}ndez and Francisco J. Diaz-Corrales and Dunja Lukovic and Irene Gonz{\'a}lez-Guede and Andrea Diez-Lloret and M Lourdes Vald{\'e}s-S{\'a}nchez and Simone Massalini and Slaven Erceg and Shomi Shanker Bhattacharya},
  journal={Stem cells},
  year={2013},
  volume={31 5},
  pages={966-78}
}
Retinitis pigmentosa (RP), a genetically heterogeneous group of diseases together with age-related macular degeneration (AMD), are the leading causes of permanent blindness and are characterized by the progressive dysfunction and death of the light sensing photoreceptors of the retina. Due to the limited regeneration capacity of the mammalian retina, the scientific community has invested significantly in trying to obtain retinal progenitor cells from embryonic stem cells (ESC). These represent… CONTINUE READING
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