Hypoxia increases stimulus-induced PAF production and release from human umbilical vein endothelial cells.

@article{Caplan1992HypoxiaIS,
  title={Hypoxia increases stimulus-induced PAF production and release from human umbilical vein endothelial cells.},
  author={Michael S. Caplan and L. H. Adler and Anne M. Kelly and Wei Hsueh},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1128 2-3},
  pages={205-10}
}
Hypoxia alters endothelial cell function and metabolism. Since PAF is synthesized by endothelial cells and capable of modulating endothelial cell responses, we investigated the effect of hypoxia on synthesis and release of PAF from endothelial cells. We found: (1) Approx. 90% of the radylPAF derivative in stimulated endothelial cells is acylPAF. (2) Acute hypoxic (15 min-1 h) priming increased ionophore- and thrombin-induced radylPAF accumulation. (3) Long-term hypoxic exposure increased… CONTINUE READING

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