Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

@inproceedings{Prickaerts2016HypoxiaIG,
  title={Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3},
  author={Peggy Prickaerts and Michiel E. Adriaens and Twan van den Beucken and Elizabeth Koch and Ludwig Dubois and Vivian E. H. Dahlmans and Caroline M M Gits and Chris T. A. Evelo and Michelle A. Chan-Seng-Yue and Bradly G. Wouters and Jan Willem Voncken},
  booktitle={Epigenetics & Chromatin},
  year={2016}
}
Trimethylation at histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) controls gene activity during development and differentiation. Whether H3K4me3 and H3K27me3 changes dynamically in response to altered microenvironmental conditions, including low-oxygen conditions commonly present in solid tumors, is relatively unknown. Demethylation of H3K4me3 and H3K27me3 is mediated by oxygen and 2-oxoglutarate dioxygenases enzymes, suggesting that oxygen deprivation (hypoxia) may influence histone… CONTINUE READING
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