Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

  title={Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3},
  author={Peggy Prickaerts and Michiel E. Adriaens and Twan van den Beucken and Elizabeth Koch and Ludwig Dubois and Vivian E. H. Dahlmans and Caroline M M Gits and Chris T. A. Evelo and Michelle A. Chan-Seng-Yue and Bradly G. Wouters and Jan Willem Voncken},
  booktitle={Epigenetics & Chromatin},
Trimethylation at histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) controls gene activity during development and differentiation. Whether H3K4me3 and H3K27me3 changes dynamically in response to altered microenvironmental conditions, including low-oxygen conditions commonly present in solid tumors, is relatively unknown. Demethylation of H3K4me3 and H3K27me3 is mediated by oxygen and 2-oxoglutarate dioxygenases enzymes, suggesting that oxygen deprivation (hypoxia) may influence histone… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 10 extracted citations


Publications referenced by this paper.
Showing 1-10 of 102 references

Quantitative analysis of ChIP‐seq data uncovers dynamic and sustained epigenetic modulation in cancer cells under hypoxia

  • M Adriaens, P Prickaerts, M Chan‐Seng‐Yue, T Beck, BG Wouters, JW Voncken
  • Epigenet Chromatin
  • 2016
Highly Influential
4 Excerpts

HIF‐1‐de‐ pendent induction of Jumonji Domain‐Containing Protein (JMJD) 3 under hypoxic conditions

  • L Ho‐Youl, C Kang, O Hookeun, P Young‐Kwon, P. Hyunsung
  • Mol Cells
  • 2014

Similar Papers

Loading similar papers…