Hypoxia increases bromodeoxyuridine labeling indices in bovine neonatal pulmonary arteries.

@article{Belknap1997HypoxiaIB,
  title={Hypoxia increases bromodeoxyuridine labeling indices in bovine neonatal pulmonary arteries.},
  author={J. K. Belknap and E. Christopher Orton and Beverly Ensley and Alan Tucker and Kurt R Stenmark},
  journal={American journal of respiratory cell and molecular biology},
  year={1997},
  volume={16 4},
  pages={366-71}
}
Thickening of peripheral pulmonary arteries (PA) in the pulmonary hypertensive neonate has been well described morphologically, but less is known regarding the role of cell proliferation in either the normal or hypertensive neonatal PA. Thus we studied DNA synthetic indices in the tunica media and tunica adventitia of four different sizes/generations of PA in normoxic calves (n = 15) and calves exposed to hypobaric hypoxia (n = 15) during the first 14 days of life. DNA synthetic indices were… CONTINUE READING