Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps.

@article{Schaible2012HypoxiaIA,
  title={Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps.},
  author={Bettina Schaible and Cormac T Taylor and Kirsten Schaffer},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 4},
  pages={2114-8}
}
Antibiotic resistance is a significant and developing problem in general medical practice and a common clinical complication in cystic fibrosis patients infected with Pseudomonas aeruginosa. Such infections occur within hypoxic mucous deposits in the cystic fibrosis lung; however, little is known about how the hypoxic microenvironment influences pathogen behavior. Here we investigated the impact of hypoxia on antibiotic resistance in P. aeruginosa. The MICs of a selection of antibiotics were… CONTINUE READING

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