Hypoxia increases LDL oxidation and expression of 15-lipoxygenase-2 in human macrophages.


OBJECTIVE Macrophage-mediated oxidation of low-density lipoprotein (LDL) by enzymes, such as the lipoxygenases, is considered of major importance for the formation of oxidized LDL during atherogenesis. Macrophages have been identified in hypoxic areas in atherosclerotic plaques. METHODS AND RESULTS To investigate the role of hypoxia in macrophage-mediated… (More)


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