Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.

@article{Li2009HypoxiaIA,
  title={Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.},
  author={Liang Li and Xiaojie Zhang and Dehua Yang and Guangrui Luo and Shen Chen and Weidong Le},
  journal={Neurobiology of aging},
  year={2009},
  volume={30 7},
  pages={
          1091-8
        }
}
Environmental factors are significant contributors for the development of Alzheimer's disease (AD). The greatly increased incidence of AD following stroke and cerebral ischemia suggests that hypoxia is a risk factor which may accelerate AD pathogenesis by altering amyloid precursor protein (APP) processing. However, the molecular mechanisms underlying the hypoxia mediated AD pathogenesis have not been fully elucidated. In the present study we demonstrated that repeated hypoxia increased beta… CONTINUE READING

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