Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells.

@article{Fantozzi2003HypoxiaIA,
  title={Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells.},
  author={Ivana Fantozzi and Shen Zhang and Oleksandr Platoshyn and Carmelle V. Remillard and Randy T. Cowling and Jason X-J Yuan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 6},
  pages={L1233-45}
}
Activating protein (AP)-1 transcription factors modulate expression of genes involved in cell proliferation and migration. Chronic hypoxia increases pulmonary artery smooth muscle cell proliferation by upregulating AP-1-responsive genes encoding for endothelium-derived vasoactive and mitogenic factors implicated in pulmonary hypertension development. The expression of AP-1 transcription factors is sensitive to changes in cytosolic free [Ca2+] ([Ca2+]cyt). Capacitative Ca2+ entry (CCE) via store… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 76 extracted citations

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie • 2016
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TRP channels in endothelial function and dysfunction.

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View 4 Excerpts
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Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells.

Advances in experimental medicine and biology • 2017
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 78 references

Endothelial cell responses to hypoxic stress.

Clinical and experimental pharmacology & physiology • 2000
View 5 Excerpts
Highly Influenced

Endothelin and pulmonary hypertension.

Journal of cardiovascular pharmacology • 2000
View 8 Excerpts
Highly Influenced

Hypoxia activates jun-N-terminal kinase, extracellular signal-regulated protein kinase, and p38 kinase in pulmonary arteries.

American journal of respiratory cell and molecular biology • 2000
View 4 Excerpts
Highly Influenced

Oxygen-regulated transcription factors and their role in pulmonary disease

Respiratory research • 2000
View 4 Excerpts
Highly Influenced

Oxygen sensing and molecular adaptation to hypoxia.

Physiological reviews • 1996
View 4 Excerpts
Highly Influenced

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