Hypoxia in the thymus: role of oxygen tension in thymocyte survival.

  title={Hypoxia in the thymus: role of oxygen tension in thymocyte survival.},
  author={Laura P. Hale and Rod D. Braun and William M. Gwinn and Paula K. Greer and Mark W. Dewhirst},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={282 4},
Our previous studies using oxygen microelectrodes showed that the thymus is grossly hypoxic under normal physiological conditions. We now have investigated how oxygen tension affects the thymus at the cellular and molecular level. Adducts of the hypoxia marker drug pimonidazole accumulated in foci within the cortex and medulla and at the corticomedullary junction, consistent with the presence of widespread cellular hypoxia in the normal thymus. Hypoxia-associated pimonidazole accumulation was… CONTINUE READING