Hypoxia in prostate cancer: correlation of BOLD-MRI with pimonidazole immunohistochemistry-initial observations.

@article{Hoskin2007HypoxiaIP,
  title={Hypoxia in prostate cancer: correlation of BOLD-MRI with pimonidazole immunohistochemistry-initial observations.},
  author={Peter J. Hoskin and Dawn M Carnell and N. Jane Taylor and Rowena E Smith and J. James Stirling and Frances M Daley and Michele I Saunders and Soeren M. Bentzen and David J. Collins and James A d'Arcy and Anwar P Padhani},
  journal={International journal of radiation oncology, biology, physics},
  year={2007},
  volume={68 4},
  pages={1065-71}
}
PURPOSE To investigate the ability of blood oxygen level-dependent (BOLD) MRI to depict clinically significant prostate tumor hypoxia. METHODS AND MATERIALS Thirty-three patients with prostate carcinoma undergoing radical prostatectomy were studied preoperatively, using gradient echo sequences without and with contrast medium enhancement, to map relative tissue oxygenation according to relaxivity rates and relative blood volume (rBV). Pimonidazole was administered preoperatively, and whole… CONTINUE READING