Hypoxia imaging markers and applications for radiation treatment planning.

  title={Hypoxia imaging markers and applications for radiation treatment planning.},
  author={Alexander Lin and Stephen M. Hahn},
  journal={Seminars in nuclear medicine},
  volume={42 5},
Tumor hypoxia presents a unique therapeutic challenge in the treatment of solid malignancies. Not only does the presence of hypoxia compromise the efficacy of locally-directed therapies, such as radiotherapy, but the proteomic and genomic changes activated by hypoxia can promote malignant progression and systemic dissemination. In an effort to improve therapeutic ratios and treatment outcomes, therapies that specifically target areas of hypoxia are actively being investigated. Therefore… CONTINUE READING
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