Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner.

@article{Bin2017HypoxiaFM,
  title={Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner.},
  author={Lucia Bin{\'o} and Jiřina Proch{\'a}zkov{\'a} and Katarzyna Anna Radaszkiewicz and Jan Ku{\vc}era and Jana Kudov{\'a} and Jiř{\'i} Pachern{\'i}k and Luk{\'a}{\vs} Kubala},
  journal={Oncotarget},
  year={2017}
}
The potentiation of the naturally limited regenerative capacity of the heart is dependent on an understanding of the mechanisms that are activated in response to pathological conditions such as hypoxia. Under these conditions, the expression of genes suggested to support cardiomyocyte survival and heart adaptation is triggered. Particularly important are changes in the expression of myosin heavy chain (MHC) isoforms. We propose here that alterations in the expression profiles of MHC genes are… Expand
HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart
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The function of HIF-1 in the heart throughout development into adulthood, as well as the deregulation of Hif-1 signaling in diabetes and its effects on the embryonic and adult heart are discussed. Expand
The influence of hypoxia on the prostate cancer proteome
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Evaluated the impact of hypoxia on the proteome of the prostate to establish whether NO-NSAID treatment reverted the protein profiles back to their normoxic status and demonstrated well-defined, significantly regulated/differentially expressed proteins primarily involved with structural and binding processes. Expand

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