Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression.

@article{Sun2006HypoxiaFA,
  title={Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression.},
  author={Xiulian Sun and Guiqiong He and Hong Hong Qing and Weihui Zhou and Frederick A. Dobie and F. F. Cai and Matthias Staufenbiel and Lei Huang and Weihong Song},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 49},
  pages={18727-32}
}
The molecular mechanism underlying the pathogenesis of the majority of cases of sporadic Alzheimer's disease (AD) is unknown. A history of stroke was found to be associated with development of some AD cases, especially in the presence of vascular risk factors. Reduced cerebral perfusion is a common vascular component among AD risk factors, and hypoxia is a direct consequence of hypoperfusion. Previously we showed that expression of the beta-site beta-amyloid precursor protein (APP) cleavage… CONTINUE READING
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