Hypoxia enhances the wound-healing potential of adipose-derived stem cells in a novel human primary keratinocyte-based scratch assay

@inproceedings{Riis2017HypoxiaET,
  title={Hypoxia enhances the wound-healing potential of adipose-derived stem cells in a novel human primary keratinocyte-based scratch assay},
  author={Simone Elkj{\ae}r Riis and Rhonda Newman and Hilal Ipek and Jens Isak Andersen and David Kuninger and Shayne E M Boucher and Mohan C. Vemuri and Cristian Pablo Pennisi and Vladimir Zachar and Trine Fink},
  booktitle={International journal of molecular medicine},
  year={2017}
}
Preclinical studies have suggested that paracrine factors from adipose-derived stem cells (ASCs) promote the healing of chronic wounds, and that the exposure of ASCs to hypoxia enhances their wound healing effect. To aid the translation of these findings into clinical use, robust wound models are necessary to explore each aspect of wound healing. The aspect of re-epithelization is often studied in a scratch assay based on transformed keratinocytes. However, there are concerns regarding the… CONTINUE READING
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