Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor.

@article{Eguchi2013HypoxiaET,
  title={Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor.},
  author={Daiki Eguchi and Naoki Ikenaga and Kenoki Ohuchida and Shingo Kozono and Lin Cui and Kenji Fujiwara and Minoru Fujino and Takao Ohtsuka and Kazuhiro Mizumoto and Masao Tanaka},
  journal={The Journal of surgical research},
  year={2013},
  volume={181 2},
  pages={225-33}
}
BACKGROUND Pancreatic cancer (PC), a hypovascular tumor, thrives under hypoxic conditions. Pancreatic stellate cells (PSCs) promote PC progression by secreting soluble factors, but their functions in hypoxia are poorly understood. This study aimed to clarify the effects of hypoxic conditions on the interaction between PC cells and PSCs. METHODS We isolated human PSCs from fresh pancreatic ductal adenocarcinomas and analyzed functional differences in PSCs between normoxia (21% O2) and hypoxia… CONTINUE READING

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