Hypoxia enhances ligand-occupied androgen receptor activity.

  title={Hypoxia enhances ligand-occupied androgen receptor activity.},
  author={Choa Park and Yiseul Kim and Myeongkuk Shim and Youngjoo Lee},
  journal={Biochemical and biophysical research communications},
  volume={418 2},
Hypoxia and the androgen receptor (AR) play important roles in the development and progression of prostate cancer. In this study, the combined effects of dihydrotestosterone (DHT) and hypoxia on AR-mediated transactivation were investigated. Hypoxia alone did not induce a detectable ARE-mediated response in the absence of DHT. DHT-induced AR transcriptional activity was dramatically increased by hypoxia or ectopic expression of HIF-1α, as determined by introducing ARE-responsive reporter… CONTINUE READING
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