Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells.

@article{Hara2006HypoxiaEC,
  title={Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells.},
  author={Shingo Hara and Koh-ichi Nakashiro and Sebastian Krystian Klosek and Tohru Ishikawa and Satoru Shintani and Hiroyuki Hamakawa},
  journal={Oral oncology},
  year={2006},
  volume={42 6},
  pages={593-8}
}
Hypoxia increases the invasive and metastatic potential of tumor cells. Increased expression of c-Met/hepatocyte growth factor (HGF)-receptor protein in response to hypoxia in thyroid papillary carcinomas is hypoxia-inducible factor-1 (HIF-1) dependent. Both HGF and c-Met are expressed in human salivary gland cancers. In the current study, we tested whether c-Met expression was regulated by hypoxia and HIF-1alpha using two human salivary gland cancer cell lines: GFP-ACC2 and GFP-ACCM. Hypoxia… CONTINUE READING

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