Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction

@article{Zhu2018HypoxiaelicitedMS,
  title={Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction},
  author={Ling-Ping Zhu and Tian Tian and Jun-Yao Wang and Jing-ni He and Tong Chen and Miao Pan and Li Xu and Hui-xin Zhang and Xueting Qiu and Chuan-chang Li and Kang-Kai Wang and Hong Shen and Guo-Gang Zhang and Yongping Bai},
  journal={Theranostics},
  year={2018},
  volume={8},
  pages={6163 - 6177}
}
Exosomes (Exo) secreted from hypoxia-conditioned bone marrow mesenchymal stem cells (BM-MSCs) were found to be protective for ischemic disease. However, the role of exosomal miRNA in the protective effect of hypoxia-conditioned BM-MSCs-derived Exo (Hypo-Exo) remains largely uncharacterized and the poor specificity of tissue targeting of Exo limits their clinical applications. Therefore, the objective of this study was to examine the effect of miRNA in Hypo-Exo on the repair of ischemic… Expand
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