Hypoxia-driven proliferation of embryonic neural stem/progenitor cells--role of hypoxia-inducible transcription factor-1alpha.

@article{Zhao2008HypoxiadrivenPO,
  title={Hypoxia-driven proliferation of embryonic neural stem/progenitor cells--role of hypoxia-inducible transcription factor-1alpha.},
  author={Tong Zhao and Cui-ping Zhang and Zhao-hui Liu and Li-ying Wu and Xin Huang and Hai-tong Wu and Lei Xiong and Xuan Wang and Xiao-min Wang and Ling-ling Zhu and Ming Fan},
  journal={The FEBS journal},
  year={2008},
  volume={275 8},
  pages={1824-34}
}
We recently reported that intermittent hypoxia facilitated the proliferation of neural stem/progenitor cells (NPCs) in the subventricule zone and hippocampus in vivo. Here, we demonstrate that hypoxia promoted the proliferation of NPCs in vitro and that hypoxia-inducible factor (HIF)-1alpha, which is one of the key molecules in the response to hypoxia, was critical in this process. NPCs were isolated from the rat embryonic mesencephalon (E13.5), and exposed to different oxygen concentrations… CONTINUE READING

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