Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells.

@article{Plans1997HypoxiaDE,
  title={Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells.},
  author={Carole Plan{\`e}s and Brigitte Escoubet and Marcel Blot-Chabaud and G{\'e}rard Friedlander and Nicolette Farman and Christine Cl{\'e}rici},
  journal={American journal of respiratory cell and molecular biology},
  year={1997},
  volume={17 4},
  pages={508-18}
}
Decrease in alveolar oxygen tension may induce acute lung injury with pulmonary edema. We investigated whether, in alveolar epithelial cells, expression and activity of epithelial sodium (Na) channels and Na,K-adenosine triphosphatase, the major components of transepithelial Na transport, were regulated by hypoxia. Exposure of cultured rat alveolar cells to 3% and 0% O2 for 18 h reduced Na channel activity estimated by amiloride-sensitive 22Na influx by 32% and 67%, respectively, whereas 5% O2… CONTINUE READING
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Subacute hypoxic challenge decreases alveolar fluid clearance in rat

  • S. Suzuki, T. Sakuma, +5 authors S. Fujimura
  • Am. J. Respir. Crit. Care Med. 153:A505
  • 1996
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