Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors.

@article{Negus1998HypoxiaDM,
  title={Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors.},
  author={R. P. M. Negus and Lynn Turner and Frances Burke and Frances R. Balkwill},
  journal={Journal of leukocyte biology},
  year={1998},
  volume={63 6},
  pages={758-65}
}
Monocyte chemoattractant protein 1 (MCP-1) is likely to contribute to the macrophage infiltrate in human ovarian carcinomas. Although MCP-1 is predominantly expressed by the tumor parenchyma, macrophages accumulate at highest density in necrotic regions, which are associated with low oxygen tensions. Tumor necrosis factor alpha (TNF-alpha) can stimulate MCP-1 production and is also present within ovarian carcinomas. We have investigated the effect of hypoxia both on MCP-1 expression in ovarian… CONTINUE READING