Hypoxia converts human macrophages into triglyceride-loaded foam cells.

Abstract

OBJECTIVE Atherosclerotic lesions have regions that are hypoxic. Because the lesion contains macrophages that are loaded with lipid, we investigated whether hypoxia can influence the accumulation of lipids in these cells. METHODS AND RESULTS Exposure of human macrophages to hypoxia for 24 hours resulted in an increased formation of cytosolic lipid… (More)

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