Hypoxia control to normalize pathologic angiogenesis: potential role for endothelial precursor cells and miRNAs regulation.

@article{Collet2012HypoxiaCT,
  title={Hypoxia control to normalize pathologic angiogenesis: potential role for endothelial precursor cells and miRNAs regulation.},
  author={Guillaume Collet and Klaudia Skrzypek and Catherine Grillon and Agata Matejuk and Bouchra El Hafni-Rahbi and Nathalie Lamerant-Fayel and Claudine Kieda},
  journal={Vascular pharmacology},
  year={2012},
  volume={56 5-6},
  pages={
          252-61
        }
}
Tumor microenvironment is a complex and highly dynamic milieu that provides very important clues on tumor development and progression mechanisms. Tumor-associated endothelial cells play a key role in stroma organization. They achieve tumor angiogenesis, a formation of tumor-associated (angiogenic) vessels mainly through sprouting from locally preexisting vessels and/or recruitment of bone marrow-derived endothelial progenitor cells. This process participates to supply nutritional support and… CONTINUE READING
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