Hypoxia and oxidative stress in breast cancer: Hypoxia and tumourigenesis

  title={Hypoxia and oxidative stress in breast cancer: Hypoxia and tumourigenesis},
  author={Helen J Knowles and Adrian L. Harris},
  journal={Breast Cancer Research : BCR},
  pages={318 - 322}
The microenvironmental hypoxia that arises as a consequence of the development of a solid tumour also acts to promote tumour growth. Hypoxia induces the expression of key components of the angiogenic and apoptotic signalling cascades, the glycolytic pathway and various cell-cycle control proteins. At the cellular level it mediates the infiltration and accumulation of tumour-associated macrophages within avascular tumour regions. Complex interactions between tumour cell and macrophage hypoxia… CONTINUE READING

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