Hypoxia and neurodegeneration.

  title={Hypoxia and neurodegeneration.},
  author={Chris S Peers and Mark L Dallas and Hannah E. Boycott and Jason L. Scragg and Hugh A Pearson and John P Boyle},
  journal={Annals of the New York Academy of Sciences},
Periods of chronic hypoxia, which can arise from numerous cardiorespiratory disorders, predispose individuals to the development of dementias, particularly Alzheimer's disease (AD). AD is characterized in part by the increased production of amyloid beta peptide (Abeta), which forms the extracellular plaques by which the disease can be identified post mortem. Numerous studies have now shown that hypoxia, even in vitro, can increase production of Abeta in different cell types. Evidence has been… CONTINUE READING
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