Corpus ID: 24278865

Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells.

@article{Plans2002HypoxiaAB,
  title={Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells.},
  author={Carole Plan{\`e}s and Marcel Blot-Chabaud and Michael A. Matthay and Sylviane Couette and Tokujiro Uchida and Christine Cl{\'e}rici},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 49},
  pages={
          47318-24
        }
}
Alveolar hypoxia may impair sodium-dependent alveolar fluid transport and induce pulmonary edema in rat and human lung, an effect that can be prevented by the inhalation of beta(2)-agonists. To investigate the mechanism of beta(2)-agonist-mediated stimulation of sodium transport under conditions of moderate hypoxia, we examined the effect of terbutaline on epithelial sodium channel (ENaC) expression and activity in cultured rat alveolar epithelial type II cells exposed to 3% O(2) for 24 h… Expand
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