Hypoxia and PDGF have a synergistic effect that increases the expression of the angiogenetic peptide vascular endothelial growth factor in Achilles tendon fibroblasts

@article{Petersen2003HypoxiaAP,
  title={Hypoxia and PDGF have a synergistic effect that increases the expression of the angiogenetic peptide vascular endothelial growth factor in Achilles tendon fibroblasts},
  author={Wolf J Petersen and Thomas Pufe and Thore Zantop and Bernhard N. Tillmann and Rolf Mentlein},
  journal={Archives of Orthopaedic and Trauma Surgery},
  year={2003},
  volume={123},
  pages={485-488}
}
Angiogenesis, the formation of new blood vessels from pre-existing vessels, is an essential step in the process of tendon healing and tendon graft remodelling, e.g. after anterior cruciate ligament reconstruction. To address the question of whether platelet-derived growth factor (PDGF) could influence vascular endothelial growth factor (VEGF) expression in tenocytes, we challenged primary cultures of rat tenocytes with different stimulators (hypoxia, PDGF) and measured their VEGF secretion. To… CONTINUE READING

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