Hypoxia and Neonatal Haemorrhagic Stroke: Experimental Study of Mechanisms.

Abstract

We studied the level of blood oxygen saturation (SpO2) in the brain in newborn rats in the pre- and post-stroke periods, as well as the changes in cerebral blood flow and beta-arrestin-1 as a marker of hypoxic stress. Our results show that mild hypoxia precedes the stroke development and is associated with venous relaxation and decrease blood outflow from the brain resulting in the elevation of synthesis of beta-arrestin-1 in the brain. The incidence of stroke is characterized by severe hypoxia, which is accompanied by the progression of pathological changes in cerebral veins and the high level of beta-arrestin-1.

DOI: 10.1007/978-3-319-38810-6_23

Cite this paper

@article{SemyachkinaGlushkovskaya2016HypoxiaAN, title={Hypoxia and Neonatal Haemorrhagic Stroke: Experimental Study of Mechanisms.}, author={Oxana V Semyachkina-Glushkovskaya and Ekaterina G Borisova and Anton Namikin and Ivan V Fedosov and Arkady Abdurashitov and Ekaterina Zhinchenko and Artem Gekalyuk and Maria Ulanova and Victoria Rezunbaeva and Latchezar A Avramov and Dan Zhu and Qingming Luo and Valery V. Tuchin}, journal={Advances in experimental medicine and biology}, year={2016}, volume={923}, pages={173-179} }