Hypoxia and HIF-1alpha in chondrogenesis.

  title={Hypoxia and HIF-1alpha in chondrogenesis.},
  author={Ernestina Schipani},
  journal={Annals of the New York Academy of Sciences},
In endochondral bone development chondrocytes undergo proliferation, hypertrophic differentiation, mineralization of the surrounding matrix, death, blood vessel invasion, and finally replacement of cartilage with bone. The chondrocytic growth plate is a unique mesenchymal tissue, as it is avascular but it requires blood vessel invasion in order to be replaced by bone. We have recently provided evidence that the growth plate is hypoxic during fetal development. Adaptation to hypoxia is a… CONTINUE READING
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