Hypoxia and HIF-1 suppress SERCA2a expression in embryonic cardiac myocytes through two interdependent hypoxia response elements.

@article{Ronkainen2011HypoxiaAH,
  title={Hypoxia and HIF-1 suppress SERCA2a expression in embryonic cardiac myocytes through two interdependent hypoxia response elements.},
  author={Veli-Pekka Ronkainen and R{\'e}ka Skoumal and Pasi Tavi},
  journal={Journal of molecular and cellular cardiology},
  year={2011},
  volume={50 6},
  pages={1008-16}
}
Sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a) is an essential component of cardiomyocyte excitation-contraction (EC)-coupling. Suppression of SERCA2a expression induces contractile dysfunction and has been reported in various forms of ischemic cardiac disease as well as in hypobaric hypoxia. The present study investigated whether SERCA2a expression is regulated by hypoxia in embryonic mouse cardiomyocytes and explored the underlying mechanism. We show that in cultured embryonic… CONTINUE READING

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